Best Topical Melatonin for Hair Loss: A Comprehensive Guide

Best Topical Melatonin for Hair Loss: A Comprehensive Guide

Hair loss is a common issue faced by millions of people worldwide. One potential solution gaining popularity in recent years is the use of topical melatonin for hair loss. Melatonin, primarily known for its role in regulating the sleep cycle, has shown promising results in promoting hair growth and reducing hair thinning when applied topically.

Studies suggest that melatonin may have a positive impact on hair growth, particularly in the early stages of hair loss or hair thinning. Topical melatonin products are available in the market, but it is essential to understand their benefits, key ingredients, and potential side effects before committing to a specific product. By using the right product and following proper application guidelines, individuals can potentially see an improvement in their hair’s overall health and growth.

Key Takeaway:

  • Topical melatonin can promote hair growth and reduce hair thinning in early-stage hair loss.
  • It is essential to choose a product with the right ingredients and understand its potential side effects.
  • Proper application guidelines should be followed to ensure the best possible results with topical melatonin.

Understanding the Concept of Topical Melatonin

Topical melatonin is a hair loss treatment that focuses on applying melatonin directly to the scalp. Melatonin, a hormone naturally produced by the body, is responsible for regulating sleep patterns and maintaining overall health. In recent years, research has discovered the potential benefits of melatonin for hair growth and preventing hair loss. This section aims to provide a brief overview of topical melatonin and its role in addressing hair loss issues.

Melatonin has been found to play an essential role in the hair growth cycle. It stimulates the growth phase (anagen) while preventing premature entry into the shedding phase (telogen). This balance is crucial for maintaining healthy hair. Topical melatonin is designed to deliver these benefits directly to the hair follicles, without the need for ingestion or systemic exposure. This direct application method helps ensure that the active ingredients reach the target site and produce the desired effect.

Various studies have shown that topical melatonin can be an effective treatment for androgenetic alopecia, a common cause of hair loss in both men and women. It is believed that melatonin’s potent antioxidant properties help protect the hair follicles from oxidative stress and damage, enabling them to function optimally.

To provide consumers with a convenient way to apply topical melatonin, various products have been developed. These include:

  • Natrol Liquid Melatonin Tincture
  • ASATONA AG’s Topically Applied Cosmetic Hair Solution
  • NutraM Hair Growth Serum
  • Night Owl® Melatonin Scalp Solution

When using topical melatonin products for hair loss, it is essential to follow the instructions provided by the manufacturer for the best results. Consistency and regular use are key factors in seeing improvements in hair growth and overall hair health.

In summary, topical melatonin offers a promising option for those struggling with hair loss. It targets the hair follicles directly, promoting growth and preventing premature shedding. By understanding the concept of topical melatonin and exploring product options, individuals can make informed decisions about whether this treatment is suitable for their needs.

The Connection Between Melatonin and Hair Loss

Melatonin is a hormone that regulates sleep and plays a role in various physiological processes. Interestingly, research has discovered a connection between melatonin and hair health. Studies have shown that melatonin has the potential to improve conditions like androgenetic alopecia (AGA), also known as pattern hair loss. In this section, we’ll explore the relationship between melatonin and hair loss and discuss how topical melatonin can be beneficial for managing hair health.

Topical melatonin has been found to influence hair growth by acting as a potent antioxidant and growth modulator. It helps in protecting hair follicles from oxidative stress, which is a significant factor contributing to hair loss. A study examined the efficacy of a topical melatonin solution in treating androgenetic alopecia. Participants applied the melatonin solution daily for 90 days, resulting in noticeable improvement in hair-thickness and hair-growth.

Researchers have also compared the effectiveness of topical melatonin to other treatments for androgenetic alopecia. In a report, it was found that melatonin solution was more effective in improving hair loss than other previously used treatments. This suggests that melatonin can indeed play a significant role in hair growth and overall hair health.

Some of the key factors that contribute to the success of topical melatonin in treating hair loss are:

  • Antioxidant properties: Melatonin is known for its ability to quench free radicals, protecting hair follicles from oxidative stress and potential damage.
  • Growth modulation: Melatonin can affect the growth cycle of hair follicles, stimulating them to enter the anagen (growth) phase and prolonging it, resulting in healthier, thicker hair.
  • Ease of application: Topical melatonin is easy to apply, making it a convenient option for those seeking alternative treatments for hair loss.

To conclude, melatonin appears to have a promising role in the treatment of androgenetic alopecia and other hair loss conditions. Its potent antioxidant properties and growth modulation abilities make it an effective option for managing hair health. Moreover, topical melatonin is a practical and cost-effective solution that can be easily incorporated into daily routines for managing hair loss and promoting stronger, healthier hair.

Top Ranked Topical Melatonin Products

In recent years, topical melatonin has gained popularity as a potential treatment for hair loss. Numerous products are available in the market, and we have gathered information on the top-ranked options to help you decide which one is best for you.

  1. Natrol Liquid Melatonin Tincture

The Natrol Liquid Melatonin Tincture is a popular choice for hair loss treatment. This product is a liquid solution containing melatonin, which is applied directly to the scalp. The formulation is designed to aid in hair growth and improve overall hair health.

  1. ASATONA AG’s Topically Applied Cosmetic Hair Solution

Another effective option is ASATONA AG’s Topically Applied Cosmetic Hair Solution. This product is specifically formulated with melatonin as an active ingredient and has shown promising results in an open-label observational study on individuals with early-stage hair loss or hair-thinning.

  1. NutraM Hair Growth Serum

The NutraM Hair Growth Serum is another popular choice endorsed by the American Hair Loss Association. This dermatologist-tested serum contains a combination of ingredients, including melatonin, to help block DHT production and stimulate hair growth for both men and women.

  1. Night Owl® Melatonin Scalp Solution

Last but not least, the Night Owl® Melatonin Scalp Solution is a top-rated melatonin-based product for hair loss. The solution is specifically designed for nighttime use and involves direct application to the scalp. It emphasizes the importance of melatonin in hair growth and aids in maintaining overall hair health.

These top-ranked products offer hope for individuals looking to treat hair loss with topical melatonin. While it is always a good idea to consult with a healthcare professional or dermatologist before starting a new hair loss treatment, these products have garnered positive reviews and offer various benefits that are worth considering.

Benefits of Using Topical Melatonin for Hair Loss

Promotes Hair Growth

Topical melatonin has been found to have positive effects on hair growth. Its antioxidant properties help combat oxidative stress that is associated with hair loss and androgenic alopecia (AGA). Supporting this, human hair follicles can synthesize melatonin and express melatonin receptors, which may aid in the promotion of hair growth.

Restores Hair Cycle

In addition to promoting hair growth, topical melatonin plays a role in regulating the sleep cycle, which can indirectly affect the hair cycle. Melatonin helps reduce stress levels, contributing to a healthier sleep pattern. With a balanced sleep cycle, the body can better regulate various physiological processes, including hair growth. A healthy hair cycle consists of three phases: anagen (growth), catagen (transitional), and telogen (resting). By restoring the sleep cycle, topical melatonin may help maintain a healthy hair cycle.

Reduces Hair Fall

Moreover, topical melatonin may reduce hair fall. Its effects on hair follicle function have been shown to alleviate hair loss by improving hair growth and possibly reducing hair fall. While it may not completely eradicate hair loss in every individual, the consistent application of a topical melatonin solution has been deemed an effective and tolerable treatment.

In summary, using topical melatonin for hair loss can provide multiple benefits, including promoting hair growth, restoring the hair cycle, and reducing hair fall. By incorporating it into your hair care routine, you may experience significant improvements in your hair health and appearance.

Key Ingredients to Look for in Topical Melatonin Products

When searching for the best topical melatonin products for hair loss, it is essential to consider the additional ingredients that may aid in hair growth and overall hair health. This section will cover three important ingredients you should look for in these products.


Biotin is a B-vitamin that plays a vital role in the health of your hair, skin, and nails. It helps in the production of keratin, a protein that is essential for hair growth. Research suggests that a biotin deficiency can lead to hair loss. Topical melatonin products containing biotin may help improve the health and strength of your hair.

  • Role in Hair Growth: Biotin helps in producing keratin, a protein necessary for hair growth.
  • Potential Benefits: Stronger, thicker, and healthier hair.
  • Recommended Concentration: Look for products containing at least 1% biotin.


Keratin is a protein that makes up the structure of hair, skin, and nails. It provides strength and resilience to your hair. Topical keratin treatments may help reduce hair breakage, promote hair growth, and improve overall hair health.

  • Role in Hair Growth: Keratin strengthens the hair shaft, reducing breakage and promoting growth.
  • Potential Benefits: Reduced hair breakage, smoother and shinier hair.
  • Recommended Concentration: Look for products with a keratin content between 0.5% to 2%.


Vitamins are essential for maintaining overall health, and certain vitamins play a crucial role in promoting hair growth. Some important vitamins to look for in topical melatonin products include:

  1. Vitamin A: Helps in the production of sebum, which keeps hair moisturized and healthy.
  2. Vitamin C: Acts as an antioxidant and aids in collagen production, contributing to hair strength.
  3. Vitamin E: Protects hair from free radicals and environmental damage, promoting hair growth.
  • Role in Hair Growth: Vitamins provide essential nutrients for hair growth and health.
  • Potential Benefits: Improved hair health, reduced hair loss, and increased hair growth.
  • Recommended Concentration: Look for products containing a blend of vitamins, with concentrations varying depending on the specific vitamin.

By considering these key ingredients in addition to melatonin, you can choose a product that provides optimal results in addressing hair loss and promoting hair growth.

Application Guidelines for Topical Melatonin

When using topical melatonin for hair loss, it’s essential to follow proper application guidelines to ensure optimal results. These guidelines will help you apply the melatonin solution correctly and maximize its potential benefits for hair growth.

Firstly, it’s crucial to clean your scalp before applying melatonin. Make sure your hair and scalp are clean and dry, as this will ensure better absorption of the product. Use a gentle shampoo to remove any dirt and oil build-up.

Next, it’s time to apply the melatonin solution to your scalp. There is no one-size-fits-all dosage, as the concentration of melatonin in various products may differ. However, most products recommend applying a small amount (usually a few drops) directly to the affected areas of the scalp. You can use your fingers or a dropper to do this. Gently massage the solution into your scalp using circular motions for better penetration.

It is generally recommended to apply topical melatonin in the evening, as this is when your body’s natural melatonin production occurs. Consistency is key, so aim to apply the solution daily for the best results.

Remember to be patient when using topical melatonin for hair loss. It may take a few months to notice any visible improvement in hair growth, and individual results can vary. Keep track of your progress by taking periodic photos of your scalp to monitor any changes.

Finally, when it comes to possible side effects, topical melatonin is generally well-tolerated and considered safe. However, if you experience any irritation, redness, or discomfort, discontinue use and consult a healthcare professional.

By following these application guidelines, you’ll maximize the benefits of using topical melatonin for hair loss treatment and promote healthy hair growth.

Potential Side Effects of Topical Melatonin

While topical melatonin has been shown to help with hair loss, it’s essential to be aware of the potential side effects. In this section, we’ll cover two common side effects of topical melatonin: Skin Irritation and Allergic Reactions.

Skin Irritation

One possible side effect of using topical melatonin is skin irritation. Some individuals may experience redness, itching, or swelling at the site of application. This could be a temporary reaction, or it may persist and worsen with continued use. If you notice any signs of irritation, it’s essential to:

  1. Clean the affected area gently with soap and water.
  2. Discontinue use of the topical melatonin product.
  3. Consult with a healthcare professional to discuss alternative treatment options.

Remember to perform a patch test before using a new topical product. Apply a small amount of the solution to a discrete area of your skin and wait for 24 hours to observe any adverse reactions.

Allergic Reactions

Although rare, some individuals may experience an allergic reaction to topical melatonin. Symptoms of an allergic reaction could include:

  • Hives or rashes
  • Difficulty breathing
  • Swelling of the face, lips, or tongue
  • Dizziness or lightheadedness

If you suspect an allergic reaction, seek medical attention immediately. It’s important to inform your doctor of any known allergies to medications or topical products before starting treatment with melatonin.

In conclusion, while topical melatonin may provide benefits for treating hair loss, it’s crucial to be aware of potential side effects. Always consult with a healthcare professional before beginning any new treatment and monitor for any adverse reactions.

Recommendations for Best Results

When using topical melatonin for hair loss, it is essential to follow certain recommendations to maximize the potential benefits. By incorporating these suggested practices, you can optimize your hair growth journey and improve the efficacy of the treatment.

Choose the right product: Selecting the appropriate topical melatonin solution is crucial. Some of the highly recommended options include Natrol Liquid Melatonin Tincture, ASATONA AG’s Topically Applied Cosmetic Hair Solution, NutraM Hair Growth Serum, and Night Owl® Melatonin Scalp Solution.

Consistency: Apply the melatonin solution regularly as per the product’s instructions. Most treatments recommended daily application, and consistency plays a significant role in achieving desired results.

Proper application: Ensure that the melatonin solution reaches the scalp. Part your hair into sections, and use a dropper or applicator to spread the product evenly. Gently massage the solution into your scalp for better absorption.

In addition to topical treatments, some lifestyle changes can support hair growth:

  • Balanced diet: Consuming a diet rich in nutrients such as biotin, zinc, and vitamins can contribute to healthy hair growth. Incorporate foods like eggs, nuts, seeds, and leafy greens in your daily routine.
  • Stress management: Stress can negatively impact hair growth. Engage in stress-relieving activities like yoga, meditation, and exercise.
  • Scalp care: Keep your scalp clean and maintain a healthy hair care routine. Avoid using harsh shampoos; opt for mild, sulfate-free formulas instead.

Remember that results may vary, and it is important to be patient and give the treatment time to work. Consulting a dermatologist or trichologist can help tailor the treatment to your specific needs and provide professional guidance.

Frequently Asked Questions

Topical melatonin has been shown to be well tolerated in clinical studies, with very few reported side effects. Some individuals might experience mild skin irritation or redness at the application site. As with any new treatment, it is essential to monitor for any adverse reactions and consult a medical professional if side effects persist or worsen. 

There have been limited direct comparisons between topical melatonin and minoxidil in treating hair loss. However, some studies suggest that topical melatonin may have a positive effect on hair growth, especially in individuals with androgenetic alopecia. Minoxidil has been extensively studied and is a well-established treatment for hair loss. Both treatments have their own merits, but it is crucial to consult with a healthcare professional to determine the best option for your specific situation.

The primary purpose of oral melatonin supplements is to regulate sleep cycles, and their impact on hair growth remains unclear. Some studies indicate oral melatonin may potentially help hair growth, but more research is required to fully confirm these findings. Topical melatonin is specifically designed for hair growth and has shown more promising results in this area.

You can find a list of recommended topical melatonin products for hair loss at websites such as Stages of Balding. It’s essential to choose a reputable brand and consult with a professional if you are unsure about a product’s quality or effectiveness.

Several studies have demonstrated that topical melatonin may aid in promoting hair growth for both men and women suffering from hair loss, although the precise mechanism is not fully understood. Results may vary depending on individual factors, and consistent use over an extended period is recommended for best outcomes. 

The recommended dosage for applying topical melatonin can vary depending on the specific product. It is essential to follow the manufacturer’s instructions or consult with a medical professional for personalized guidance. In most cases, daily application to the affected areas of the scalp is advised for optimal results.

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